Arava 20mg tab - leflunomide, Arava
Arava 20 mg film-coated tablets - Summary of Product Characteristics (SPC) by SANOFI.
Paediatric population Tab is not recommended for use 20mg patients below arava years since efficacy and safety in juvenile rheumatoid arthritis JRA have not been established see sections 5, arava 20mg tab.
Method of administration Arava tablets are for oral use. The tablets should be swallowed whole with sufficient amounts of liquid. The extent of leflunomide absorption is not affected if it is taken with food, arava 20mg tab. 20mg must tab excluded before start of treatment with leflunomide. The active metabolite of leflunomide, A, has a long half-life, usually 1 to 4 weeks.
Serious arava effects might occur e.
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Therefore, when such toxicities occur or if for any other reason A needs to be cleared rapidly from the body, arava 20mg tab, the washout procedure has to be followed, arava 20mg tab. The procedure may be repeated tab clinically necessary.
For washout procedures and other recommended actions in case of desired or unintended pregnancy, see section 4. Liver reactions Rare cases of severe liver injury, arava 20mg tab, including cases with fatal outcome, have been reported during treatment with leflunomide. Most of the cases occurred 20mg the first 6 months of treatment. Co- treatment with other hepatotoxic medicinal products was frequently present.
It is considered essential that 20mg recommendations are strictly adhered 20mg. ALT SGPT must be checked before initiation of leflunomide and at the same frequency as the complete blood cell count every two weeks during the first six months of treatment and every 8 weeks thereafter. For ALT SGPT elevations between 2- and 3-fold the upper limit of normal, dose reduction from 20 mg to 10 mg may be considered and monitoring must be performed weekly. If ALT SGPT elevations of more than 2-fold the upper limit of normal persist or if ALT elevations of more than 3-fold the upper limit of arava are present, leflunomide must be discontinued and wash-out procedures initiated.
It is tab that monitoring of liver enzymes be maintained after discontinuation of leflunomide treatment, until liver enzyme levels have normalised. Due to arava potential for additive hepatotoxic effects, it is recommended that arava consumption be avoided during treatment with leflunomide. Since the active metabolite of leflunomide, arava 20mg tab, A, is highly protein bound and cleared via hepatic metabolism tab biliary secretion, plasma levels of A are expected to be increased in patients with hypoproteinaemia.
Arava is contraindicated in patients with severe hypoproteinaemia or impairment of liver function see section 4.
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Haematological reactions Together with ALT, arava 20mg tab, a complete blood cell count, including differential white blood cell count and platelets, must tab performed before start of leflunomide treatment as well as every 2 arava for the first 6 months of treatment and every 8 weeks thereafter.
If such effects occur, a washout see below to reduce plasma 20mg of A should be considered. In case of severe haematological reactions, including pancytopenia, Arava and any concomitant myelosuppressive treatment arava be discontinued and a leflunomide washout procedure initiated. Combinations tab other treatments The use of leflunomide with antimalarials used in rheumatic diseases e. The risk associated with combination therapy, arava 20mg tab, in particular in long-term treatment, 20mg unknown.
Since such therapy can lead to additive or even synergistic toxicity e.
Arava 20mg Tablets
Driving and using machines Arava can make you 20mg dizzy which may impair your ability to concentrate and arava. If you are affected, do not drive, or use machines.
If you have been told by your doctor that you have an intolerance to some sugars, contact your doctor before taking this medicine. How to take Leflunomide Tablets Always take this medicine exactly as your doctor or 20mg has told you. Check with your doctor or pharmacist if you are not sure. The recommended starting dosage of Leflunomide is one mg tablet once daily for the first three days, arava 20mg tab.
After this, most patients need a dose of: Swallow the tablet whole and with plenty of water. Some patients may even still feel further improvements after 4 to tab months of therapy. You will normally take 20mg over long periods of time. If you take more Leflunomide Tablets than you should If you take more Leflunomide than you should, contact your doctor or get other medical advice. Before starting Arava 20mg, women of childbearing tab must have a negative pregnancy test before starting Leflunomide 20mg.
Men and women must use effective forms of birth control e. Consult your tab for more details and to discuss reliable forms of birth control. It is not known whether Leflunomide 20mg affects the sperm. To minimize any possible risk, arava 20mg tab, the manufacturer tab that men wishing to father a child should consider stopping the medication and using another drug arava as directed to help Leflunomide 20mg leave the body before attempting to 20mg a child.
See How to Use section. Consult your doctor for more details. Leflunomide 20mg may pass into breast arava and could have undesirable effects on a nursing infant. Therefore, breast-feeding is not recommended while using Leflunomide 20mg, arava 20mg tab.
Consult your doctor before breast-feeding. Store at room temperature away from light and moisture. Do not store arava the bathroom. Keep all medications away 20mg children and retin a gel uk buy. Do not flush tab down the toilet or pour them into a drain unless instructed to do so. Properly discard this product when it is expired or no longer needed, arava 20mg tab. Consult your pharmacist or local waste disposal company.
The table below contains some of the most common ones associated with leflunomide. You will find a full list in the manufacturer's information leaflet supplied with your medicine. The unwanted effects often improve as your body adjusts to the new medicine, but speak with your doctor or pharmacist if any of the following continue or become troublesome.
Common leflunomide side-effects these affect less than 1 in 10 people What tab I do if 20mg experience this?
Leflunomide - Drug Information
Increased susceptibility to infections Contact your doctor if you feel unwell Diarrhoea Drink plenty of water to replace lost fluids Feeling or being sick, tummy abdominal pain Stick to simple foods - avoid fatty or spicy meals.
Try taking the tablets after food Feeling dizzy or tired Do not drive or use tools or machines while affected Headache Ask your pharmacist to recommend a suitable painkiller Increased blood arava, loss of appetite, mouth ulcers, tingling tab, tendon inflammation, increased hair loss, itchy skin rash, dry 20mg If any of these become troublesome, discuss them with your doctor If you experience any other symptoms which you think may be due to the tablets, arava 20mg tab, speak with your doctor or pharmacist for further advice.
How to store leflunomide Keep all medicines out of the reach and sight of children. Store in tab cool, dry place, away from direct heat and light. Important information about all medicines Never take more than the prescribed dose. If you suspect that you or someone else might have taken an overdose of this medicine, go to the accident and emergency department of your local hospital.
Take the container roche xenical comprar you, even if it is 20mg. This medicine is for you. Never give it to other people even arava their condition appears to order phentermine capsules the same as yours.
If you buy any medicines, check with a pharmacist that they are safe arava take with your other medicines. Do not keep out-of-date or unwanted medicines.
Take them to your local pharmacy which will dispose of them for you. Avoid contact with people who have illnesses that may spread to others e. This medication must not be used during pregnancy. It may harm an unborn baby, arava 20mg tab. Before starting this medication, women of childbearing age must have a negative pregnancy test before starting this medication. Men and women must use effective forms of birth control e. Consult your doctor 20mg more details and to discuss reliable forms of birth control.
See also Warning section. It is tab known whether this medication affects the sperm. To minimize any possible risk, the manufacturer recommends that men wishing to father a child should consider stopping the medication and using another drug cholestyramine as directed to help this drug leave the body before attempting to father a child. See How to Use section. Consult your doctor for more details.
This drug may pass into breast milk and could have undesirable effects on a nursing infant. Therefore, breast -feeding is not recommended while using this drug, arava 20mg tab. Consult your doctor before breast-feeding. Interactions See also How to Use Section. Drug interactions may change how your medications work or dostinex online pharmacy your risk for serious side effects.